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WebJan 1, 2024 · Chemoresistance cancer Metastases 1. Introduction Tetraspanins, also known as TSPANs or transmembrane 4 superfamily (TM4SF) proteins, are a family of proteins highly conserved between species. TSPANs display numerous functions that indicate their biological and physiological importance in cell motility, adhesion and proliferation. WebThe relevant mechanisms that can contribute to cellular resistance include: increased expression of defense factors involved in reducing intracellular drug concentration; alterations in drug-target interaction; and changes in cellular response, in particular increased cell ability to repair DNA damage or tolerate stress conditions, and defects in … mario party island tour victory
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